The Lipotropic Action of Threonine and Related Substances in the R,4t* By
نویسندگان
چکیده
With the discovery of threonine through its essentiality in the growth of the rat, it became possible to raise animals on synthetic diets completely devoid of protein (l-3). However, the metabolic fate of this amino acid is still largely unknown today. Its importance in the growth of microorganisms (4) and in the maintenance of nitrogen equilibrium in older animals (5-7) has been demonstrated. nn-Threonine and the stereoisomer nr,-allothreonine are glycogen formers and can decrease the ketonuria resulting from butyric acid (8). The synthesis of glycine from these amino acids has been reported (9). Threonine prevents the nephrotoxic effect of nn-serine (10) in rats and antagonizes the same amino acid in lactic acid bacteria (11). In a recent report from this laboratory it was shown that fatty livers could be produced in rats on low casein or amino acid rations containing a suboptimal amount of threonine (12). It seemed of importance, therefore, to assay the lipotropic action of some compounds related to threonine in order to determine the existence of any relationship between structural specificity and the prevention of fatty livers. The data obtained with D-, L-, and nn-threonine, nn-allothreonine, and DL-homoserine are presented here.
منابع مشابه
SYNTHESIS AND DETERMINATION OF THE LIPOTROPIC ACTIVITY OF THE BETAINE HYDROCHLORIDES OF dl-SERINE, GTHREONINE, AND dl-ALLOTHREONINE*
This paper reports the synthesis of the betaine hydrochlorides of serine, threonine, and allothreonine and a study of the action of these substances on the lipid content of the livers of rats fed a high fat, low protein diet. This work was undertaken for two purposes. Best and Huntsman (1) found that choline prevented the development of fatty livers in rats fed a high fat diet and that betaine ...
متن کاملSYNTHESIS AND DETERMINATION OF THE LIPOTROPIC ACTIVITY OF THE BETAINE HYDROCHLORIDES OF dl-SERINE, GTHREONINE, AND dl-ALLOTHREONINE*
This paper reports the synthesis of the betaine hydrochlorides of serine, threonine, and allothreonine and a study of the action of these substances on the lipid content of the livers of rats fed a high fat, low protein diet. This work was undertaken for two purposes. Best and Huntsman (1) found that choline prevented the development of fatty livers in rats fed a high fat diet and that betaine ...
متن کاملEffects of Dietary Threonine and a Multi Strains Probiotic (Primalac) Supplementation on Growth Performance, Blood Metabolites and Carcass Characteristics in Japanese Quails
The objective of this study was to investigate the effects of three levels of threonine (100, 95 and 90% of NRC requirements) with or without of multi strains probiotic (Primalac) on performance, carcass characteristics and blood metabolites of Japanese quails. A total of 180 one-day-old male Japanese quails were randomly allocated to six treatments with three replicates and 10 birds per each. ...
متن کاملOn the lipotropic action of protein.
The lipotropic action of protein, which was first recognized in 1935 (1, 2), has been the subject of many investigations (3-6). These have centered largely around the question of whether the lipotropic activity of a protein can be attributed entirely to it,s content of cystine and methionine. Evidence has been presented on both sides of the controversy that has arisen (6-ll), and, although some...
متن کامل